Intraperitoneal Steroid Therapy for Recurrent Malignant Ascites in Advanced Cancer Patients: A Case Series

Area of Science:

• Oncology
• Gastroenterology
• Pharmacology

Background:

• Recurrent malignant ascites is a common complication of advanced cancers.
• Paracentesis is a standard treatment but requires frequent repetition.
• Managing ascites impacts patient quality of life.

Purpose of the Study:

• To evaluate the efficacy of intraperitoneal depot corticosteroids in managing malignant ascites.
• To determine if this treatment reduces ascitic fluid re-accumulation.
• To assess the impact on the interval between paracentesis procedures.

Main Methods:

• Patients with recurrent malignant ascites received an initial paracentesis.
• Depot corticosteroids were administered intraperitoneally following the procedure.
• Ascitic fluid formation and paracentesis intervals were monitored.

Main Results:

• Intraperitoneal depot corticosteroid administration significantly reduced the rate of ascitic fluid formation.
• The interval between required paracentesis sessions was extended.
• Patients experienced improved quality of life metrics.

Conclusions:

• Intraperitoneal depot corticosteroids are an effective option for managing recurrent malignant ascites.
• This therapeutic approach can decrease the burden of ascites management.
• The treatment offers a potential to enhance the quality of life for patients with malignant ascites.