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Intrapleural Steroid Therapy for Recurrent Malignant Pleural Effusion: A Case Report
Shima Rani Sarker1, Imtiaz Faruq1, Jheelam Biswas2
1Bangladesh Medical University (BMU) Dhaka Bangladesh.
Clinical Case Reports
|September 8, 2025
Summary
Intrapleural triamcinolone acetate offers a palliative approach for malignant pleural effusion (MPE). This corticosteroid treatment delayed fluid buildup and improved symptoms in a recurrent MPE case.
Area of Science:
- Oncology
- Pulmonology
- Palliative Care
Background:
- Malignant pleural effusion (MPE) is a frequent complication in advanced cancers.
- MPE significantly impacts patient quality of life, primarily through dyspnea.
Purpose of the Study:
- To evaluate the efficacy of intrapleural triamcinolone acetate in managing recurrent MPE.
- To explore the potential mechanism of action for intrapleural corticosteroids in MPE.
Main Methods:
- A case study of a 57-year-old woman with recurrent MPE.
- Management with intrapleural triamcinolone acetate administration.
Main Results:
- Delayed fluid reaccumulation by 15 days.
- Improved patient symptoms and functional status.
- No observed adverse effects.
Conclusions:
- Intrapleural corticosteroids, like triamcinolone acetate, represent a viable palliative option for recurrent MPE.
- This approach is particularly relevant when conventional treatments are unsuitable.
- VEGF inhibition and reduced vascular permeability are potential mechanisms.
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