Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bacterial Signaling01:30

Bacterial Signaling

31.5K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
31.5K
Amplifying Signals via Enzymatic Cascade01:22

Amplifying Signals via Enzymatic Cascade

8.3K
When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze...
8.3K
Biofilms01:29

Biofilms

Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ROS-Balancing MXene/MoSe<sub>2</sub> Hybrids Combat Drug-Resistant Bacteria and Accelerate Tissue Regeneration in Cutaneous Wounds.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Deciphering Augmented Dual-ROS-Driven Biofilm Eradication by Facilitating Long-Range Spatial Charge Decoupling in Polymer Carbon Dots.

Angewandte Chemie (International ed. in English)·2026
Same author

Organic-inorganic heterostructure empowers infected wound healing.

Journal of materials chemistry. B·2025
Same author

Tailoring Full-Spectrum Solvatofluorochromic Carbon Dots: Deciphering Tunable Multicolor Emission Mechanisms toward Advanced Photonic Cryptography.

Nano letters·2025
Same author

Glucose microenvironment-primed nanocatalytic membranes for rapid bacterial eradication and infected diabetic wound regeneration.

Journal of materials chemistry. B·2025
Same author

Oxygen-Independent Sulfate Radical and Fe<sup>2+</sup>-Modified Implants for Fast Sterilization and Osseointegration of Infectious Bone Defects.

ACS nano·2025

Related Experiment Video

Updated: Jun 4, 2025

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
12:19

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Published on: July 1, 2013

10.8K

Multi-Functional Bio-HJzyme Engineered Polyetheretherketone Implant with Cascade-Amplification Therapeutic

Jing Gong1,2, Shuangquan Lai1, Shuting Zhang1

  • 1State Key Laboratory of Oral Diseases, School of Chemical Engineering, National Center for Stomatology & National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, 610041, China.

Small (Weinheim an Der Bergstrasse, Germany)
|December 31, 2024
PubMed
Summary

Engineered implants with a novel coating combat diabetic implant-associated infections. This multi-functional bio-heterojunction enzyme coating uses photothermal therapy and biocatalysis to eliminate bacteria and promote tissue healing.

Keywords:
antibacterialbio‐heterojunctioncascade‐amplification therapyimplant‐associated infectionspolyetheretherketone

More Related Videos

High-Dimensionality Flow Cytometry for Immune Function Analysis of Dissected Implant Tissues
08:21

High-Dimensionality Flow Cytometry for Immune Function Analysis of Dissected Implant Tissues

Published on: September 15, 2021

2.1K
A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
06:18

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

Published on: March 3, 2023

1.3K

Related Experiment Videos

Last Updated: Jun 4, 2025

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
12:19

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Published on: July 1, 2013

10.8K
High-Dimensionality Flow Cytometry for Immune Function Analysis of Dissected Implant Tissues
08:21

High-Dimensionality Flow Cytometry for Immune Function Analysis of Dissected Implant Tissues

Published on: September 15, 2021

2.1K
A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
06:18

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

Published on: March 3, 2023

1.3K

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Infectious Diseases

Background:

  • Implant-associated infections (IAIs) are a major cause of prosthetic failure, especially in diabetic patients.
  • Current treatments for diabetic IAIs are often insufficient, necessitating advanced therapeutic strategies.
  • Engineered implants with integrated therapies are crucial for overcoming these challenges.

Purpose of the Study:

  • To develop a versatile, multi-functional implant coating for treating intractable diabetic IAIs.
  • To integrate cascade amplification therapeutic modalities for enhanced antibacterial efficacy.
  • To improve outcomes for diabetic patients suffering from implant-associated infections.

Main Methods:

  • A multi-functional MXene/Ag3PO4@glucose oxidase bio-heterojunction enzyme (M/A@GOx bio-HJzyme) coating was developed.
  • The coating was applied to a sulfonated polyetheretherketone implant (SP-M/A@G) using hydrothermal treatment and layered deposition.
  • The implant's efficacy was evaluated through in vitro cell studies and in vivo assessments in a diabetic infection model.

Main Results:

  • The M/A@GOx bio-HJzyme coating enhanced osteoblast adhesion and proliferation.
  • Upon 808 nm near-infrared (NIR) light irradiation, the coating induced hyperthermia, reactive oxygen species (ROS) generation, Fenton-like and laccase-mimicking reactions, and glutathione (GSH) depletion.
  • The engineered implants demonstrated robust cyclic antibacterial properties, effectively eradicated pathogens, and promoted diabetic infectious skin regeneration in vivo.

Conclusions:

  • The developed multi-functional bio-heterojunction enzyme coating offers a revolutionary approach for treating diabetic IAIs.
  • The cascade amplification of phototherapy and biocatalytic therapy provides potent cyclic antibacterial effects.
  • This strategy holds significant promise for improving the management of intractable diabetic implant-associated infections and promoting tissue regeneration.