ROS-Balancing MXene/MoSe₂ Hybrids Combat Drug-Resistant Bacteria and Accelerate Tissue Regeneration in Cutaneous...

Area of Science:

• Biomaterials Science
• Nanotechnology
• Wound Healing Research

Background:

• Chronic skin wounds face challenges from multidrug-resistant (MDR) bacterial infections and persistent oxidative stress, hindering inflammation resolution and regeneration.
• Current treatments, primarily antibiotic-based, are often insufficient for effectively managing these complex wound environments.

Purpose of the Study:

• To design and develop a novel reactive oxygen species (ROS)-balancing material for treating chronic skin wounds with multifactorial pathologies.
• To investigate the integrated antibacterial and oxidative stress-regulating capabilities of the MXene/MoSe2 (MX/Mo) composite.

Main Methods:

• Synthesis of MoSe2 on MXene surfaces via a solvothermal method to create the MX/Mo composite.
• Evaluation of MX/Mo under ultrasound activation for antibacterial efficacy against MDR bacteria by disrupting their energy metabolism.
• Assessment of MX/Mo's ROS-scavenging activity (without ultrasound) for alleviating oxidative stress during wound healing.

Main Results:

• Ultrasound-activated MX/Mo effectively eradicated MDR bacteria by inducing ROS and blocking adenosine triphosphate synthesis.
• MX/Mo without ultrasound demonstrated significant multienzyme-like activity, scavenging residual ROS and reducing oxidative injury.
• In vivo studies showed superior antibacterial and wound healing efficacy, suppressing Methicillin-resistant Staphylococcus aureus infections and promoting angiogenesis and collagen deposition.

Conclusions:

• The MX/Mo composite effectively integrates antibacterial activity and oxidative stress regulation for treating complex skin wounds.
• This dual-action approach offers a promising strategy for managing bacterial infection-driven disorders and promoting tissue regeneration.