Analysis of Liver Function Tests in Dengue Infected Patients

Area of Science:

• Hepatology
• Infectious Diseases
• Virology

Background:

• Dengue is a significant global public health concern.
• Dengue virus infection presents with diverse clinical manifestations.
• Liver dysfunction is a frequently observed complication in dengue patients.

Purpose of the Study:

• To assess the prevalence and extent of liver dysfunction in dengue-infected individuals.
• To evaluate the impact of dengue virus on liver function tests (LFTs).
• To correlate LFT abnormalities with dengue severity and patient outcomes.

Main Methods:

• Observational, cross-sectional study design.
• Analysis of biochemical liver function tests from 120 serologically confirmed dengue cases.
• Classification of patients into dengue fever (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS).

Main Results:

• Elevated alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were observed in 73.0% and 88.0% of patients, respectively.
• Significant elevations in ALT, AST, and total bilirubin were noted in patients with hemorrhage and non-survivors.
• Lower serum albumin levels were associated with Dengue Shock Syndrome (DSS).

Conclusions:

• Hepatic dysfunction is common across all dengue infection types.
• AST elevation may serve as an early indicator of dengue infection.
• Abnormalities in ALT, bilirubin, and albumin can be poor prognostic markers in dengue management.