Related Experiment Video
Updated: Jun 4, 2025

Analysis of Craniomaxillofacial Malformations in Mice Using Three-dimensional Microcomputed Tomography
Published on: January 17, 2025
Correlations of facial soft tissue thicknesses with craniometric dimensions improve craniofacial identification
Te Wai Pounamu T Hona1, Carl N Stephan1
1Laboratory for Human Craniofacial and Skeletal Identification (HuCS-ID Lab), School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland, Australia.
Abstract:
Linear regression (LR) models that use cranial dimensions to estimate facial soft tissue thicknesses (FSTTs) have been posited by Simpson and Henneberg to assist craniofacial identification. For these regression equations to work well, the independent (craniometrics) and dependent (FSTTs) variables must be tightly correlated; however, such relationships have not been routinely demonstrated for adult humans. To examine the strength of these relationships further, this study employed magnetic resonance (MR) imaging to unambiguously measure cranial dimensions and FSTTs for 38 adult cadavers. This contrasts with prior published use of (a) spreading calipers to compress the face in an attempt to measure cranial dimensions through the soft tissues of the head and (b) needle puncture to measure the FSTT (a + b = legacy methods). To provide direct comparisons to prior work, this study also conducted legacy measurements for reproducibility tests. Previously published LR models were not supported by either the legacy or MR data. In the MR data, correlations between the cranial dimensions and FSTTs were generally weak with a mean absolute r = 0.13 and r range = -0.40 to 0.33. Compared to previously published arithmetic means, LR models did not improve FSTT estimates in the MR sample (SEE for LR = 5.5 mm; SEE for arithmetic mean = 5.2 mm). Using the latest MR imaging technologies, these results underscore prior warnings that cranial dimensions hold weak correlations with FSTTs and possess limited utility for improved FSTT estimation over and/or above arithmetic means.
Related Concept Videos
Overview of the Skull
The cranial vault surrounds and protects the brain and houses the middle and inner ear structures. This cavity is bounded superiorly by the rounded top of the skull, which...
Muscles for Facial Expressions
Sutures of the Skull
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
Cranial Bones: Superior and Posterior View
The frontal bone is the single bone that forms the forehead. At its anterior midline, between the eyebrows, there is a slight depression called the glabella. The frontal bone also forms the supraorbital margin of the orbit. Near the middle of this margin is the supraorbital foramen, the opening that provides passage for a sensory nerve to the forehead. The frontal bone is thickened just above each supraorbital margin,...
Cranial Bones: Lateral View
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...

