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Related Experiment Video

Updated: Jun 4, 2025

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Intestinal organoids: The path towards clinical application.

Hady Yuki Sugihara1, Ryuichi Okamoto1, Tomohiro Mizutani1

  • 1Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.

European Journal of Cell Biology
|December 31, 2024
PubMed
Summary
This summary is machine-generated.

Intestinal organoids offer powerful in vitro models for studying diseases and developing therapies. Standardization is crucial for translating these stem cell-derived models into clinical applications for personalized medicine.

Keywords:
Clinical applicationDrug screeningIntestinal organoidsPersonalized medicineRegenerative medicineTissue engineering

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Area of Science:

  • Biotechnology
  • Stem Cell Biology
  • Gastroenterology

Background:

  • Organoids, 3D in vitro models of human organs, have significantly advanced biological research.
  • Intestinal organoids, derived from stem cells, are pivotal for studying intestinal biology and disease.
  • Despite progress, challenges hinder the clinical translation of intestinal organoids for diagnosis and therapy.

Purpose of the Study:

  • To review the translational research of intestinal organoids derived from adult stem cells and pluripotent stem cells.
  • To highlight advances and limitations in disease modeling, drug screening, personalized medicine, and stem cell therapy using intestinal organoids.
  • To emphasize the need for standardized frameworks to facilitate clinical translation.

Main Methods:

  • Review of preclinical studies on intestinal organoids.
  • Analysis of stem cell-derived intestinal organoid models.
  • Evaluation of applications in disease modeling, drug screening, and personalized medicine.

Main Results:

  • Intestinal organoids successfully recapitulate infectious and genetic diseases.
  • Patient-specific intestinal organoids show reliability as avatars for personalized studies.
  • Advanced organoid models now capture complex intestinal pathophysiology.

Conclusions:

  • Intestinal organoids show great promise for clinical applications, including disease modeling and personalized medicine.
  • Standardized protocols for generation, culture, storage, and analysis are essential for clinical translation.
  • Further development is needed to fully realize the potential of intestinal organoids in healthcare.