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Published on: March 4, 2014
Idiopathic Multiple Localized Lipoatrophy Mimicking Amyotrophic Lateral Sclerosis
Shuhei Mashimo1, Ayano Matsuoka2, Keiji Tanese1
1Department of Dermatology, Toho University School of Medicine, Tokyo, JPN.
Abstract:
Localized lipoatrophy is a rare condition characterized by the localized loss of subcutaneous adipose tissue. It may occur idiopathically without specific triggers. The pathogenesis of idiopathic localized lipoatrophy remains largely unknown. We present the case of a 53-year-old Japanese woman with multiple localized lipoatrophy who exhibited upper motor neuron signs clinically and panniculitis histologically. She was initially suspected to have amyotrophic lateral sclerosis due to progressive left limb volume loss. Histologically, the lesions showed adipocyte destruction accompanied by predominant plasma infiltration.
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