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Insights into the different mechanisms of Autophagy and Apoptosis mediated by Morbilliviruses

Rashmi Singh1, Sharad Kumar Gaur1, Rakhi Nagar1

  • 1Department of Microbiology, University of Delhi South Campus, New Delhi, 110021, India.

Virology
|January 1, 2025
PubMed

Insights

Morbilliviruses manipulate host cell death pathways, including autophagy and apoptosis, to ensure their survival and spread. Understanding this interplay offers potential therapeutic strategies against these viruses.

Area of Science:

  • Virology
  • Cell Biology
  • Immunology

Background:

  • Viruses are obligate intracellular parasites that evolve alongside their hosts.
  • Viruses can evade host immunity by altering host proteins involved in critical cellular processes.
  • Programmed cell death, including autophagy and apoptosis, is a key host defense against viral infections.

Purpose of the Study:

  • To investigate how Morbilliviruses modulate autophagy and apoptosis pathways.
  • To understand the interplay between autophagy and apoptosis during Morbillivirus infection.
  • To explore the therapeutic potential of targeting these pathways in Morbillivirus infections.

Main Methods:

  • This study focuses on the molecular mechanisms by which Morbilliviruses interact with host cell death pathways.
  • Analysis involves understanding viral strategies to utilize or inhibit autophagy and apoptosis.
  • The research explores the crosstalk between these two programmed cell death mechanisms.

Main Results:

  • Morbilliviruses can hijack autophagosomes for replication, delaying apoptosis.
  • These viruses can also induce apoptosis to enhance viral dissemination.
  • There is a complex interplay between autophagy and apoptosis that dictates the outcome of infection.

Conclusions:

  • Morbilliviruses actively modulate both autophagy and apoptosis to their advantage.
  • The interaction between these pathways is crucial for viral survival and spread.
  • Targeting Morbillivirus-induced modulation of autophagy and apoptosis presents a promising therapeutic avenue.
Keywords:
ApoptosisAutophagyCell deathMorbillivirusOncolytic therapy

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