Related Experiment Video
Updated: Jun 4, 2025
A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
Published on: August 12, 2020
Neonatal sepsis in Vietnam: Bacterial profiles and antibiotic susceptibility in a tertiary care setting
Thi Quynh Nga Nguyen1, Thi Huong Giang Do2, Thi Van Nguyen2
1Department of Pediatrics, Hanoi Medical University, Ha Noi, Vietnam; Neonatal Center, Vietnam National Children's Hospital, Hanoi, Vietnam.
Background:
Neonatal sepsis is a leading cause of newborn mortality, particularly in low- and middle-income countries. This study examines the bacterial etiologies and antibiotic resistance patterns of neonatal sepsis in a tertiary hospital in Vietnam.
Methods:
A prospective cross-sectional study was conducted at National Children's Hospital, Hanoi, Vietnam from January 2021 to December 2022. All neonates with a clinical suspicion of sepsis and a confirmed positive blood culture were identified. Isolated pathogens were identified, and antibiotic susceptibility was assessed using standard protocols.
Results:
In total, 202 neonates were diagnosed with proven sepsis. Among these, 75.2% of cases referred from other hospitals. Early-onset sepsis accounted for 15.8% of these infections. Gram-negative bacteria were responsible for 75.7% of the cases, with Klebsiella pneumoniae being the most prevalent pathogen (32.2%), followed by Staphylococcus aureus (14.9%), and both Serratia marcescens and Escherichia coli (10.9% each). Gram-negative bacteria showed significant resistance to third-generation cephalosporins, carbapenems, while gram-positive bacteria demonstrated considerable resistance to clindamycin and oxacillin. However, most gram-positive isolates were susceptible to vancomycin, and gram-negative bacteria had lower resistance to colistin and fosfomycin.
Conclusions:
These findings highlight the critical importance of continuous surveillance and tailored antibiotic policies to combat neonatal sepsis effectively.
