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Updated: Jun 4, 2025

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
Published on: April 13, 2022
[Single-cell spatiotemporal atlas of tooth development: progress and prospects]
1The Stomatology Center and Research Center of Oral and Maxillofacial Development and Regeneration of Xiangya Hospital; Academician Workstation for Oral & Maxillofacial Regenerative Medicine, Central South University, Changsha410008, China.
Abstract:
Single-cell and spatial multi-omics technologies enable the simultaneous analysis of thousands of cells in various states, revealing their transcriptional profiles, chromatin accessibility, and spatial positioning. Recent advances in single-cell multi-omics have led to significant discoveries regarding the definition, function, evolution, and interaction of various cell subtypes during tooth development. We summarize key findings from recent single-cell multi-omics studies on tooth development, highlighting their contributions to the field and discussing future perspectives in dental developmental genomics research.

