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Sjogren's syndrome: a persistent clinical problem.

R C Bone, R I Fox, F V Howell

    The Laryngoscope
    |March 1, 1985
    PubMed
    Summary
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    Sjogren's syndrome diagnosis uses corneal exams and lip biopsies. While typically managed non-surgically, surgical intervention may be needed for complications like infection or malignant transformation.

    Area of Science:

    • Rheumatology and Immunology
    • Ophthalmology
    • Otorhinolaryngology (Head and Neck Surgery)

    Background:

    • Sjogren's syndrome is an autoimmune disorder affecting exocrine glands, primarily causing dry eyes and dry mouth.
    • Diagnosis often involves clinical examination and specific tests to confirm keratoconjunctivitis sicca (KCS) and salivary gland involvement.
    • The head and neck surgeon plays a role in managing complications and evaluating symptoms of "dry mouth".

    Purpose of the Study:

    • To review the diagnostic methods and management strategies for Sjogren's syndrome.
    • To discuss the surgical considerations for Sjogren's syndrome patients.
    • To explore the potential etiology of Sjogren's syndrome, including genetic and immunogenic factors.

    Main Methods:

    • Evaluation and management of 160 patients with Sjogren's syndrome at Scripps Clinic.

    Related Experiment Videos

  • Objective diagnostic tools included rose-bengal vital staining and corneal slit lamp examination for KCS.
  • Lip biopsy was utilized for salivary gland assessment.

    • Main Results:

    • Sjogren's syndrome is primarily managed non-surgically.
    • Complications such as abscess, recurrent infection, disfigurement, and malignant transformation may necessitate total parotidectomy with nerve preservation.
    • Radiation therapy is rarely indicated for Sjogren's syndrome.

    Conclusions:

    • Sjogren's syndrome diagnosis relies on a combination of clinical findings and objective tests.
    • Surgical intervention is reserved for specific, severe complications.
    • The etiology may involve a homogeneous genetic background and chronic immunogenic stimuli.