Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spent ternary lithium-ion battery-derived NiCo/MnO@CC interfacial catalyst modulates Li<sub>2</sub>CO<sub>3</sub> deposition in Li-CO<sub>2</sub> batteries.

Chemical communications (Cambridge, England)·2026
Same author

Reply to "Beyond Association: Proposing a Clinically Actionable NLR-Sarcopenia Risk Stratification Tool for Post-Acute Care Settings".

Journal of the American Medical Directors Association·2026
Same author

Atomic Evolution of Hydrogen Intercalation Wave Dynamics in Palladium Nanocrystals Revealed by Liquid-Phase Transmission Electron Microscopy.

Journal of the American Chemical Society·2026
Same author

Synergistic Immunomodulation and Angiogenesis-Driven Microenvironment Remodeling via Bioactive Hydrogel/Nanofiber Composites for Enhanced Infectious Wound Healing.

Advanced healthcare materials·2026
Same author

Development and internal validation of an interpretable machine-learning model for identifying comorbid atrial fibrillation in patients with diabetic kidney disease.

Frontiers in clinical diabetes and healthcare·2026
Same author

Augmenting large language models with clinical knowledge graph for personalized perioperative fluid therapy question answering.

PLOS digital health·2026

Related Experiment Video

Updated: Jun 4, 2025

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications
09:56

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications

Published on: December 8, 2015

10.7K

Rational Fabrication of Functionally-Graded Surfaces for Biological and Biomedical Applications.

Tong Wu1, Xiaoran Li2, Jiajia Xue3

  • 1Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266000, P. R. China.

Accounts of Materials Research
|January 2, 2025
PubMed
Summary

This study details methods for creating graded surfaces essential for biological functions like nerve repair and wound healing. These surfaces mimic natural tissue transitions, aiding in tissue engineering and understanding cell behavior.

More Related Videos

A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size
13:46

A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size

Published on: October 17, 2016

8.6K
Multiscale Structures Aggregated by Imprinted Nanofibers for Functional Surfaces
06:14

Multiscale Structures Aggregated by Imprinted Nanofibers for Functional Surfaces

Published on: September 11, 2018

6.5K

Related Experiment Videos

Last Updated: Jun 4, 2025

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications
09:56

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications

Published on: December 8, 2015

10.7K
A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size
13:46

A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size

Published on: October 17, 2016

8.6K
Multiscale Structures Aggregated by Imprinted Nanofibers for Functional Surfaces
06:14

Multiscale Structures Aggregated by Imprinted Nanofibers for Functional Surfaces

Published on: September 11, 2018

6.5K

Area of Science:

  • Materials Science
  • Cell Biology
  • Biomedical Engineering

Background:

  • Graded surfaces, with gradual changes in composition or structure, are crucial for biological processes such as embryonic development, wound healing, and tissue integration.
  • Understanding and fabricating these graded materials is vital for advancing regenerative medicine and tissue engineering applications.

Purpose of the Study:

  • To review efforts in fabricating and utilizing functionally graded surfaces for biological and biomedical applications.
  • To present novel strategies for generating surface gradations with controlled composition, structure, and molecular/cellular coverage.

Main Methods:

  • Two primary strategies for generating surface gradations are discussed: a vertical deposition method and a moving collector/mask technique during jet printing or electrospray.
  • These methods allow for controlled, gradual changes in surface properties along the substrate.

Main Results:

  • Demonstrated applications include promoting neurite outgrowth for peripheral nerve repair, accelerating cell migration for wound closure, and mimicking the tendon-to-bone enthesis for interfacial tissue engineering.
  • Surface gradations can be uniaxial or radial and integrated with underlying structural features for specific applications.

Conclusions:

  • The developed fabrication strategies offer versatile approaches to creating functionally graded surfaces for diverse biological and biomedical applications.
  • Further research into the diversity of surface gradations and fabrication reproducibility is expected to drive innovation in fundamental biological inquiries and clinical translation.