Related Experiment Video
Updated: May 7, 2025

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
A case of paediatric seasonal eosinophilic oesophagitis
S Vande Velde1, J Willekens2, R De Bruyne1
1Pediatric gastroenterology, Ghent university hospital, Ghent, Belgium.
Insights
Aeroallergens like grass pollen may trigger eosinophilic esophagitis (EoE) flares. Seasonal treatment adjustments for EoE, especially during allergy season, can improve patient outcomes.
Area of Science:
- Allergy and Immunology
- Gastroenterology
- Pediatric Medicine
Background:
- Eosinophilic esophagitis (EoE) is a chronic allergic inflammatory condition of the esophagus.
- Triggers for EoE include food allergens and increasingly recognized aeroallergens.
- EoE management often involves topical steroids, but seasonal variations in triggers are being investigated.
Abstract:
Eosinophilic esophagitis (EoE) is a chronic disorder characterized by eosinophilic inflammation of the oesophagus triggered by food allergens and possibly aeroallergens. We present a boy with the diagnosis of EoE at the age of 4 years and the disease responded to topical steroids. When he turned 7 years old he had the concomitant diagnose of grass pollen allergy. A clear difference between both histological (October 2019: 0 eosinophils (Eo's)/High Power Field (HPF), April 2022: 80 Eo's/ HPF) and clinical signs (October 2019: pediatric eoe symptom score (PEESS) 3/100, April 2022: PEESS 31/100) is evident when comparing winter to spring. The boy is currently only using topical budesonide during grass pollen season. There are increasing arguments in favour of aeroallergens as a trigger for EoE. This information is important for determining the timing of endoscopic follow-up. And it may be beneficial to consider upgrading treatment during allergy season, or exclusively administering treatment during allergy season.
Related Concept Videos
Gastroesophageal Reflux Disease II: Clinical Features and Management
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Barrett Esophagus-II: Clinical Manifestations and Management
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
Esophageal Strictures-I: Introduction
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Esophageal Strictures-II: Clinical Features and Management
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Endoscopic Studies I: Bronchoscopy and Thoracoscopy
Bronchoscopy
Description
Bronchoscopy is a procedure that involves direct visualization of the larynx, trachea, and bronchi for diagnostic and therapeutic purposes. A flexible fiber optic or rigid bronchoscope is used to carry out the procedure. The fiber-optic bronchoscope is more frequently used due...
Barrett Esophagus-I: Introduction
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...

