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Volumetric Additive Manufacturing for Cell Printing: Bridging Industry Adaptation and Regulatory Frontiers.
Vidhi Mathur1, Vinita Dsouza1, Varadharajan Srinivasan2
1Manipal Centre for Biotherapeutics Research, Manipal Academy of Higher Education, Manipal, 576104 Karnataka, India.
ACS Biomaterials Science & Engineering
|January 2, 2025
Summary
Volumetric additive manufacturing (VAM) enables rapid 3D cell printing for tissue engineering. Addressing regulatory and scalability challenges is crucial for VAM
Area of Science:
- Biotechnology
- Regenerative Medicine
- Tissue Engineering
Background:
- Volumetric additive manufacturing (VAM) offers rapid fabrication of complex 3D cellular structures.
- Existing VAM techniques include holographic lithography, digital light processing, and volumetric projection.
- VAM shows promise for mimicking natural tissues in industrial applications.
Purpose of the Study:
- To explore the advantages and limitations of various VAM techniques.
- To assess the suitability of VAM across diverse industrial applications.
- To address challenges in regulatory compliance and scalability for bioprinted tissues.
Main Methods:
- Review of existing volumetric additive manufacturing techniques.
- Analysis of industrial applications and suitability of VAM.
- Examination of regulatory and scalability challenges in bioprinting.
Main Results:
- VAM techniques demonstrate potential for complex tissue mimicry.
- Regulatory and scalability hurdles impede widespread adoption of VAM in bioprinting.
- India faces specific challenges due to unclear regulatory guidelines and IP protection.
Conclusions:
- Collaboration between industry, regulators, and academia is essential for VAM advancement.
- Tailored frameworks are needed to promote innovation while ensuring safety and efficacy.
- Bridging technological and regulatory gaps will unlock VAM's potential in regenerative medicine and tissue engineering.
