Related Experiment Video
Updated: May 7, 2025
06:26
Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
Published on: January 24, 2025
808
Innovations in Drug Delivery Systems for Biologics: Enhancing Stability and Targeted Delivery for Next-Generation
Pushpendra Kumar1, Ankit Goel1, Biswajit Dash2
1Maharaja Agrasen Himalayan Garhwal University, Pokhra, Pauri Garhwal, Uttarakhand, India, 246169.
Summary
Advanced drug delivery systems (DDS) significantly enhance biologic stability and targeted delivery. Nanoparticles offer high precision, while microneedles improve patient compliance, indicating promising therapeutic outcomes.
Area of Science:
- Biotechnology
- Pharmaceutical Sciences
- Materials Science
Background:
- Biologics represent a rapidly growing class of therapeutics, but their clinical application is often limited by poor stability and targeted delivery.
- Conventional drug delivery systems (DDS) face challenges in effectively administering complex biologic molecules.
Purpose of the Study:
- To evaluate recent innovations in drug delivery systems (DDS) for biologics.
- To assess the impact of DDS on biologic stability, targeted delivery, patient compliance, and controlled release.
- To identify optimal DDS strategies for next-generation therapeutics.
Main Methods:
- Comprehensive review of peer-reviewed literature, clinical trials, and technical reports on various DDS.
- Comparative analysis of nanoparticles, microneedles, hydrogels, and biodegradable polymers using a radar chart.
- Evaluation of system performance based on stability, targeted delivery, patient compliance, and controlled release metrics.
Main Results:
- Nanoparticles demonstrated 92% precision in targeted delivery and 85% improvement in stability.
- Microneedles achieved 88% patient compliance with moderate improvements in other areas.
- Biodegradable polymers and hydrogels showed balanced enhancements, with hydrogels achieving 89% in controlled release.
Conclusions:
- Recent DDS advancements significantly improve biologic stability and targeted delivery.
- Hydrogels and microneedles excel in controlled release and patient compliance, respectively.
- Hybrid DDS strategies combining the strengths of multiple systems are recommended for future research to overcome current limitations and enhance therapeutic outcomes.
Related Concept Videos
01:28Biopharmaceutics and Pharmacokinetics: Overview
1.7K
Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...
1.7K
01:16Drug Delivery: Overview
243
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
243
01:22Drug Delivery: Miscellaneous Routes
269
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
269
01:20Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
146
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
146
01:25Routes of Drug Administration: Parenteral
1.8K
The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
1.8K
01:23Factors Affecting Dissolution: Particle Size and Effective Surface Area
588
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
588