Updates on the conversion of nanosuspensions to solid oral dosage forms.

Area of Science:

• Pharmaceutical Science
• Materials Science
• Drug Delivery

Background:

• Pharmaceutical nanosuspensions (nanocrystals) are aqueous dispersions of insoluble drug particles.
• Liquid nanosuspensions face stability challenges.
• Solid dosage forms offer advantages by combining nanocrystal benefits with solid-state properties.

Purpose of the Study:

• To review advances in nanosuspension stabilization and production.
• To present in-depth updates on methods for converting nanosuspensions into solid oral dosage forms.
• To highlight novel formulations for enhancing the bioavailability of poorly soluble drugs.

Main Methods:

• Review of literature on nanosuspension stabilization and production.
• In-depth analysis of methods for solid dosage form conversion (e.g., spray drying, freeze drying, granulation, hot-melt extrusion, printing).
• Focus on emerging formulations like nano-cocrystals and nanocrystalline solid dispersions.

Main Results:

• Spray drying and freeze drying are widely employed for nanosuspension solidification.
• Granulation and hot-melt extrusion facilitate downstream processing.
• Printing technology offers potential for personalized dosing.
• Novel formulations like nano-cocrystals and solid dispersions show promise for improved drug dissolution and bioavailability.

Conclusions:

• Solidification is a key strategy to overcome liquid nanosuspension instability.
• Various advanced methods exist for creating solid nanocrystal dosage forms.
• Emerging nano-formulations hold significant potential for improving therapeutic outcomes for poorly soluble drugs.