Recent progress in biopolymer-based electrospun nanofibers and their potential biomedical applications: A review

Tissue engineering offers an alternative approach to developing biological substitutes that restore, maintain, or enhance tissue functionality by integrating principles from medicine, biology, and engineering. In this context, biopolymer-based electrospun nanofibers have emerged as attractive platforms due to their superior physicochemical properties, including excellent biocompatibility, non-toxicity, and desirable biodegradability, compared to synthetic polymers. Considerable efforts have been dedicated to developing suitable substitutes for various biomedical applications, with electrospinning receiving considerable attention as a versatile technique for fabricating nanofibrous platforms. While the applications of biopolymer-based electrospun nanofibers in the biomedical field have been previously reviewed, recent advancements in the electrospinning technique and its specific applications in areas such as bone regeneration, wound healing, drug delivery, and protein/peptide delivery remain underexplored from a material science perspective. This work systematically highlights the effects of biopolymers and critical parameters, including polymer molecular weight, viscosity, applied voltage, flow rate, and tip-to-collector distance, on the resulting nanofiber properties. The selection criteria for different biopolymers tailored to desired biomedical applications are also discussed. Additionally, the challenges and limitations associated with biopolymer-based electrospun nanofibers, alongside future perspectives for advancing their biomedical applications, are rationally analyzed.