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AIDS-related mycoses: advances, challenges, and future directions

Rachael Dangarembizi1, Jennifer Claire Hoving2, David R Boulware3

  • 1Department of Human Biology, Neuroscience Institute, University of Cape Town, Cape Town, South Africa; CMM AFRICA Medical Mycology Research Unit, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

Trends in Microbiology
|January 5, 2025
PubMed

Insights

Fungal infections remain a significant threat for people with HIV/AIDS. Recent expert meetings identified key advances in managing AIDS-related mycoses and highlighted ongoing needs in diagnosis, treatment, and research.

Area of Science:

  • Infectious Diseases
  • Mycology
  • Public Health

Background:

  • Fungal infections are a leading cause of death in individuals with Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS).
  • Significant progress has been made in reducing mortality from these infections.

Purpose of the Study:

  • To address critical knowledge and management gaps in AIDS-related mycoses.
  • To review recent scientific advancements and identify future research priorities.

Main Methods:

  • Convening of experts including researchers, clinicians, industry professionals, and policymakers.
  • Discussion and identification of scientifically driven milestones and unmet needs.

Main Results:

  • Several key advancements have substantially decreased deaths attributed to fungal infections in the context of HIV/AIDS.
  • Persistent challenges remain in the diagnosis, treatment, and research of AIDS-related mycoses.

Conclusions:

  • Continued collaborative efforts are essential to overcome existing challenges in managing fungal infections in people with HIV/AIDS.
  • Further research and improved diagnostic and therapeutic strategies are crucial to reduce the burden of AIDS-related mycoses.
Keywords:
HIV/AIDSantifungal immunityfungal infectionsmycosesopportunistic infections

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