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Updated: Jun 3, 2025
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Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
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Are cathepsins a risk factor for papillary thyroid carcinoma? A bidirectional two-sample mendelian randomization
Zhen Sun1, Huarong Chen1, Changya Li1
1Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550004, China.
Summary
This study found cathepsin Z (CTSZ) is linked to an increased risk of papillary thyroid carcinoma (PTC). This suggests CTSZ may aid in early PTC prediction and guide treatment strategies.
Area of Science:
- Oncology
- Genetics
- Biochemistry
Background:
- Papillary thyroid carcinoma (PTC) is the most common endocrine tumor with rising incidence.
- Cathepsins, cysteine protein hydrolases, are implicated in malignant progression of various tumors, including PTC.
- The causal link between cathepsins and PTC requires further investigation.
Purpose of the Study:
- To investigate the causal relationship between cathepsins and papillary thyroid carcinoma (PTC).
- Utilized a bidirectional two-sample Mendelian randomization (MR) analysis.
Main Methods:
- Employed publicly available databases for cathepsin and PTC data.
- Screened single nucleotide polymorphisms (SNPs) as instrumental variables.
- Evaluated causality using five methods, with heterogeneity and sensitivity analyses for result stability.
Main Results:
- A significant association was observed between cathepsin Z (CTSZ) and increased PTC risk (IVW, OR = 1.170, P = 0.011).
- Inverse analysis did not reveal a significant association (IVW, OR = 1.006, P = 0.612).
- Heterogeneity and sensitivity analyses confirmed the stability and reliability of the findings.
Conclusions:
- Confirmed the association between cathepsin Z (CTSZ) and elevated papillary thyroid carcinoma (PTC) risk.
- Findings suggest CTSZ may be valuable for early PTC prediction and screening.
- Results offer potential guidance for developing therapeutic strategies targeting CTSZ.
