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Calasparagase Pegol Induced Hemolytic Anemia

Ariel Nash1, Christine Nguyen Dinh2, Jitesh Kawedia3

  • 1Department of Pediatrics, The University of Texas MD Anderson Cancer Hospital, Houston, Texas, USA.

Pediatric Blood & Cancer
|January 6, 2025
PubMed
Summary

No abstract available in PubMed .

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Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...