[Ferroptosis and liver diseases]

Area of Science:

• Hepatology
• Cell Death Research
• Metabolic Disease

Background:

• The liver is central to metabolism and nutrient regulation.
• Ferroptosis, iron-dependent programmed cell death, is linked to liver disease pathogenesis.
• It influences acute and chronic liver conditions, including fibrosis and cancer.

Purpose of the Study:

• To review the role of ferroptosis in diverse liver diseases.
• To explore ferroptosis's impact on disease progression.
• To highlight ferroptosis as a therapeutic target for liver diseases.

Main Methods:

• Literature review of ferroptosis research in liver diseases.
• Analysis of ferroptosis's dual role in disease acceleration and deceleration.
• Synthesis of current understanding of ferroptosis mechanisms in liver pathology.

Main Results:

• Ferroptosis accelerates acute liver injury, metabolic dysfunction-associated fatty liver disease, alcoholic liver disease, viral hepatitis, and autoimmune hepatitis.
• Ferroptosis can slow disease progression in advanced liver fibrosis and hepatocellular carcinoma.
• Targeting ferroptosis presents a promising avenue for liver disease management.

Conclusions:

• Ferroptosis plays a complex, context-dependent role in liver disease.
• Modulating ferroptosis is a potential therapeutic strategy for various liver conditions.
• Further research into ferroptosis mechanisms can guide novel treatment development.