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Microfluidic-based electrically driven particle manipulation techniques for biomedical applications
Jiulin Wang1, Xinyuan Cui2, Wei Wang1
1Institute of Nano Biomedicine and Engineering, School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai JiaoTong University Shanghai 200240 PR China aaron.lin@sjtu.edu.cn dxcui@sjtu.edu.cn.
RSC Advances
|January 6, 2025
Summary
Microfluidic chips offer fast, economical biomolecule separation and detection. This review covers electrically driven methods like electrophoresis and their applications in analyzing nucleic acids, proteins, and cells.
Area of Science:
- Biotechnology
- Analytical Chemistry
- Microfluidics
Background:
- Microfluidic chips offer significant advantages in speed and cost-effectiveness for biomolecule analysis.
- Electrically driven techniques are crucial for precise manipulation and separation within microfluidic systems.
Purpose of the Study:
- To review the mechanisms of various electrically driven methods used in microfluidics.
- To discuss the applications of these methods in biomolecular analysis and cell treatment.
- To outline key considerations for designing and manufacturing microfluidic chips.
Main Methods:
- Introduction to electrophoresis, dielectrophoresis, electro-wetting, and electro-rotation mechanisms.
- Detailed discussion of applications in nucleic acid analysis, protein manipulation, and cell treatment.
- Considerations for material selection, manufacturing, and structural design.
Main Results:
- Electrically driven microfluidic methods provide efficient platforms for complex biological analyses.
- Diverse applications demonstrated, including genetic analysis, protein sorting, and cellular studies.
- Design and fabrication factors significantly impact microfluidic chip performance.
Conclusions:
- Microfluidic chips utilizing electrically driven techniques are powerful tools for rapid and economical biomolecule separation and detection.
- Further advancements in chip design and material science will enhance their utility in biological research and diagnostics.
- This review provides a comprehensive overview for researchers in the field.
