[Extrahepatic cholestasis due to pancreas fibrosis in a trotter]

A trotter stallion showing symptoms of emaciation was suspected of disease of the liver associated with cholestasis in view of clinical symptoms (poor appetite, sluggishness, jaundice and oedema) and the results of examination of the blood (increased concentrations of gamma-glutamyl, transpeptidase, sorbitol dehydrogenase, alkaline phosphatase, aspartate aminotransferase and markedly increased conjugated bilirubin). A specimen removed at biopsy of the liver revealed the presence of portal fibrosis and severe cholestasis. At autopsy, it was found that very extensive fibrosis of the pancreas (probably due to migrating larvae of parasites) had caused extrahepatic cholestasis accompanied by fibrosis of the liver. The lesions of the coronary border, which were also present in this horse, could not be accounted for.