Retinal glia in myopia: current understanding and future directions.
Pengfan Chen1, Jing Ji1, Xinyi Chen2
1Department of Ophthalmology, Laboratory of Optometry and Vision Sciences, Department of Optometry and Visual Science. West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Frontiers in Cell and Developmental Biology
|January 6, 2025
Summary
Myopia involves eye elongation and thinning, affecting vision. This review explores how retinal glial cells, including astrocytes, Müller cells, and microglia, may contribute to myopia development and progression.
Area of Science:
- Ophthalmology
- Neuroscience
- Cell Biology
Background:
- Myopia is a significant global health issue characterized by axial eye elongation and thinning of retinal layers.
- The precise role of diverse retinal glial cell populations in myopia pathogenesis remains incompletely understood.
Purpose of the Study:
- To review current knowledge on the involvement of retinal glia in myopia.
- To identify future research directions concerning glial cells in myopia.
Main Methods:
- Literature review of studies investigating retinal glia in myopia.
- Analysis of the functions of astrocytes, Müller cells, and microglia in the context of myopia.
Main Results:
- Astrocytes may influence oxygen supply, neuronal function, and signal conduction through astrogliosis.
- Müller cells act as mechanosensors, responding to stretching in myopia.
- Microglia may display reactive morphology and heightened inflammatory responses in myopia.
Conclusions:
- Retinal glia, including astrocytes, Müller cells, and microglia, are implicated in the complex mechanisms of myopia.
- Further research is needed to elucidate the specific contributions and therapeutic potential of targeting retinal glia in myopia.
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