An overview of palladium-catalyzed N-alkylation reactions
Soyal Sabu1, Padinjare Veetil Saranya2, Gopinathan Anilkumar1,2,3
1Institute for Integrated Programmes and Research in Basic Sciences (IIRBS), Mahatma Gandhi University, Priyadarsini Hills P O, Kottayam, Kerala 686 560, India.
Abstract:
N-Alkylation of amines is a vital reaction in the synthesis of numerous bioactive compounds and materials. Among transition metals, palladium has emerged as a particularly effective catalyst for these transformations. The unique advantages of palladium arise from its superior catalytic efficiency, ability to operate under mild conditions, high selectivity and recyclability. Additionally, palladium facilitates the borrowing hydrogen methodology, offering sustainable and environmentally friendly alternatives. This review covers advancements in palladium-catalyzed N-alkylation reactions. The mechanistic insights and practical applications are discussed, providing a comprehensive overview of the current state of research and future directions in this field, covering literature up to 2024.
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