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Effect of postoperative extradural morphine on lower urinary tract function.

S Husted, J C Djurhuus, H C Husegaard

    Acta Anaesthesiologica Scandinavica
    |February 1, 1985
    PubMed
    Summary
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    Postoperative extradural morphine can affect lower urinary tract function in women after uterine surgery. Some patients experienced acute urinary retention, which may be reversed with naloxone.

    Area of Science:

    • Anesthesiology
    • Urology
    • Pharmacology

    Background:

    • Postoperative pain management often involves opioids.
    • Epidural morphine is used for analgesia after gynecological surgery.
    • Potential side effects on lower urinary tract function require investigation.

    Purpose of the Study:

    • To evaluate the impact of extradural morphine on lower urinary tract function post-uterine surgery.
    • To assess the incidence and characteristics of urinary retention associated with epidural morphine.
    • To explore the efficacy of naloxone in managing morphine-induced urinary retention.

    Main Methods:

    • Urodynamic measurements (cystometry, urethral pressure profilometry) were performed preoperatively and postoperatively.
    • Patients received extradural morphine for pain management.

    Related Experiment Videos

  • Comparison of urodynamic parameters between patients with and without urinary retention.
  • Administration of intravenous naloxone to patients with retention.

    • Main Results:

    • Ten patients showed no significant changes in cystometry with morphine.
    • Two patients developed acute urinary retention, characterized by increased bladder capacity and detrusor pressure.
    • Urethral pressure profiles remained unchanged in all patients.
    • Naloxone administration showed a trend towards normalizing bladder capacity in patients with retention.

    Conclusions:

    • Extradural morphine can significantly affect lower urinary tract function in a subset of patients.
    • Acute urinary retention following extradural morphine is a potential complication.
    • Naloxone may be an effective treatment for morphine-induced urinary retention.