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Proteomic Insights into the Molecular Correlations Between Coronary Artery Disease and Peripheral Artery Disease in

Aaliyah Tucker, Maggie Nguyen, Kalyani Kottilil

    Medrxiv : the Preprint Server for Health Sciences
    |January 7, 2025
    PubMed

    Insights

    Researchers explored unique biological pathways in coronary artery disease (CAD) and peripheral artery disease (PAD) using proteomics. They identified specific proteins linked to each condition, offering insights for personalized treatments.

    Area of Science:

    • Cardiovascular Science
    • Proteomics
    • Translational Medicine

    Background:

    • Coronary artery disease (CAD) and peripheral artery disease (PAD) are prevalent atherosclerotic conditions.
    • Despite shared risk factors, the distinct pathophysiological pathways of CAD and PAD remain incompletely understood.

    Purpose of the Study:

    • To differentiate common versus unique biological pathways in CAD and PAD.
    • To identify novel protein biomarkers associated with these conditions.

    Main Methods:

    • Proteomics profiling of plasma samples from Project Baseline Health Study (PBHS) participants.
    • Statistical analysis to associate protein levels with coronary artery calcium (CAC) scores and ankle-brachial index (ABI).

    Main Results:

    • 14 proteins were associated with a high CAC score (≥100).
    • 39 proteins were associated with a low ABI.
    • Two proteins, complement component 7 (C7) and polymeric immunoglobulin receptor (PIGR), showed significant association with both CAC and ABI.

    Conclusions:

    • Proteomics analysis reveals distinct molecular pathways underlying CAD and PAD.
    • Identified proteins, including C7 and PIGR, may serve as biomarkers.
    • Findings suggest potential for personalized therapeutic strategies in managing atherosclerotic diseases.

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