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Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Updated: Jun 3, 2025

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Enhancing Inner Area Revaluation Through Optional Control Programmes for Infectious Bovine Rhinotracheitis and

Alessandra Mazzeo1, Nicola Rossi2, Vincenzo Di Chiro2

  • 1Department of Agricultural, Environmental and Food Sciences (DiAAA), University of Molise, Via Francesco de Sanctis snc, 86100 Campobasso, Italy.

International Journal of Environmental Research and Public Health
|January 8, 2025
PubMed
Summary

Implementing optional animal disease programs in remote European regions can mitigate economic losses and support sustainable farming. This approach aids in managing zoonotic diseases, benefiting public health and rural communities.

Keywords:
Crohn’s diseaseIBRMAPinner areasone healthoptional eradication programmesparatuberculosis/Johne’s diseasesuspected zoonotic diseasese

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Area of Science:

  • Animal Health
  • Veterinary Regulations
  • Zoonoses Management

Background:

  • EU Regulation 2016/429 mandates management of transmissible animal diseases, including zoonoses.
  • Commission Implementing Regulation 2018/1882 categorizes diseases with specific response strategies.
  • European Inner Areas face challenges like remoteness and depopulation, impacting agriculture.

Purpose of the Study:

  • To evaluate the potential of optional animal disease programs in supporting European Inner Areas.
  • To mitigate productivity losses and economic impacts on farms in these regions.
  • To align animal health strategies with broader EU policies like the European Green Deal.

Main Methods:

  • Analysis of EU regulations on animal disease management (2016/429 and 2018/1882).
  • Assessment of challenges and potential of European Inner Areas (e.g., Molise Region).
  • Evaluation of optional disease control programs for diseases like Infectious Bovine Rhinotracheitis and Paratuberculosis.

Main Results:

  • Optional programs can reduce productivity losses from specific animal diseases.
  • These programs can enhance economic viability in remote agricultural areas.
  • Implementation supports animal welfare, pasture conservation, and reduces zoonotic disease risks.

Conclusions:

  • Optional animal disease and zoonoses programs offer a viable strategy for vulnerable European regions.
  • Such programs contribute to economic sustainability, rural development, and public health.
  • Integrating optional programs aligns with One Health principles and sustainable farming goals.