Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

192
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
192
Antidepressant Drugs: Overview01:25

Antidepressant Drugs: Overview

356
Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
356
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs01:28

Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs

299
Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
299
Depression: Overview01:18

Depression: Overview

213
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
213
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

42
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
42
Long-term Depression01:03

Long-term Depression

2.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Autoimmune Neuromuscular Disorders at a Molecular Crossroad: Linking Pathogenesis to Targeted Immunotherapy.

International journal of molecular sciences·2025
Same author

Fluid Biomarkers in Demyelinating Spectrum Disorders: Past, Present, and Prospects.

International journal of molecular sciences·2025
Same author

Cardiovascular Dysautonomia in Patients with Parkinson's Disease and Hypertension: A Cross-Sectional Pilot Study.

Journal of clinical medicine·2025
Same author

Understanding the Complex Dynamics of Immunosenescence in Multiple Sclerosis: From Pathogenesis to Treatment.

Biomedicines·2024
Same author

Neuroplasticity in Parkinson's disease.

Journal of neural transmission (Vienna, Austria : 1996)·2024
Same author

Health-Related Quality of Life in Romanian Patients with Dystonia: An Exploratory Study.

Journal of clinical medicine·2024

Related Experiment Video

Updated: Jun 3, 2025

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

600

Exploring the Complex Relationship Between Antidepressants, Depression and Neurocognitive Disorders.

Monica Neațu1,2, Iulia Ioniță1,2, Ana Jugurt1,2

  • 1Department of Clinical Neurosciences, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Biomedicines
|January 8, 2025
PubMed
Summary

Co-occurring dementia and depression in seniors requires integrated treatment. Antidepressants may offer neuroprotection but carry risks, necessitating personalized care strategies for optimal outcomes.

Keywords:
antidepressantscognitive declinedementiadepression

More Related Videos

Animal Models of Depression - Chronic Despair Model CDM
05:47

Animal Models of Depression - Chronic Despair Model CDM

Published on: September 23, 2021

7.1K
A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

20.8K

Related Experiment Videos

Last Updated: Jun 3, 2025

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

600
Animal Models of Depression - Chronic Despair Model CDM
05:47

Animal Models of Depression - Chronic Despair Model CDM

Published on: September 23, 2021

7.1K
A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

20.8K

Area of Science:

  • Geriatrics
  • Neuroscience
  • Psychiatry

Background:

  • Dementia and depression frequently coexist in older adults, creating a complex clinical challenge.
  • Depression is a known risk factor for dementia, and each condition can worsen the other.
  • Concurrent management is vital to prevent disease progression and cognitive decline.

Purpose of the Study:

  • To explore the intricate relationship between depression and dementia in older populations.
  • To examine the potential neuroprotective benefits and risks associated with antidepressant use in this demographic.
  • To highlight the need for personalized treatment strategies balancing mental health and cognitive protection.

Main Methods:

  • Literature review and synthesis of existing research on depression, dementia, and antidepressant efficacy.
  • Analysis of studies investigating the impact of antidepressants on neurogenesis, synaptic plasticity, and neuroinflammation.
  • Examination of research on antidepressant effects on Alzheimer's-related pathologies, including amyloid-beta and tau.

Main Results:

  • Antidepressants may offer neuroprotective effects, potentially slowing cognitive decline by promoting neurogenesis and reducing inflammation.
  • Some evidence suggests antidepressants can mitigate Alzheimer's pathologies like amyloid-beta accumulation and tau hyperphosphorylation.
  • Treatment-resistant depression is common in older adults with cognitive impairment, and some studies indicate antidepressants might increase dementia risk in undiagnosed cases.

Conclusions:

  • Integrated treatment approaches are essential for managing comorbid depression and dementia in the elderly.
  • Antidepressant therapy presents a dual potential for neuroprotection and risk, requiring careful consideration.
  • Personalized, comprehensive strategies are crucial to optimize mental health and cognitive outcomes in older adults with these conditions.