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Replicative Cell Senescence02:15

Replicative Cell Senescence

3.6K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
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Mitochondria01:37

Mitochondria

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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Telomeres and Telomerase02:41

Telomeres and Telomerase

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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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What is the Cell Cycle?01:04

What is the Cell Cycle?

198.9K
The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the original...
198.9K
What are Cells?01:07

What are Cells?

173.8K
Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
173.8K

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Updated: Jun 3, 2025

Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

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Editorial for Special Issue "Cellular Senescence: Recent Cellular Advances and Discoveries".

Karen Carmelina Crasta1,2,3,4, Francesca Faggioli5,6

  • 1Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117456, Singapore.

Biomedicines
|January 8, 2025
PubMed
Summary

Cellular senescence, a state of irreversible cell cycle arrest, is a key factor in aging and cancer. Understanding senescence mechanisms offers new therapeutic strategies for age-related diseases and cancer treatment.

Area of Science:

  • Gerontology and Oncology
  • Cellular Biology
  • Molecular Mechanisms of Aging

Background:

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  • Cellular senescence is a fundamental biological process implicated in aging and cancer.
  • Senescence plays a dual role, acting as a tumor suppressor mechanism but also contributing to age-related pathologies.
  • Recent advancements highlight the complexity and therapeutic potential of targeting senescent cells.