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Autoantibodies Targeting G-Protein-Coupled Receptors and RAS-Related Molecules in Post-Acute COVID Vaccination
Mauro Mantovani1, Paolo Bellavite2, Serafino Fazio3
1Istituto di Medicina Biologica, 20129 Milano, Italy.
Biomedicines
|January 8, 2025
Summary
Post-acute COVID vaccination syndrome (PACVS) involves autoantibodies against ACE2, MAS1, and STAB1, potentially serving as biomarkers. Further research is needed to understand this condition following vaccination.
Area of Science:
- Immunology
- Vaccinology
Background:
- Post-acute COVID vaccination syndrome (PACVS) is an emerging condition with unclear immunopathology.
- It shares symptoms with post-viral syndromes but follows SARS-CoV-2 vaccination.
Purpose of the Study:
- To investigate the immunopathological underpinnings of PACVS.
- To identify potential autoantibody biomarkers associated with PACVS symptoms.
Main Methods:
- Retrospective case series of 17 healthy individuals vaccinated against SARS-CoV-2.
- Analysis of medical records and serological tests for autoantibodies.
Main Results:
- Subjects with PACVS showed antibodies against G protein-coupled receptors and SARS-CoV-2 response molecules.
- Specific autoantibodies (anti-ACE2, anti-MAS1, anti-STAB1) correlated with symptoms like skin issues and burning sensations.
- Anti-ADRA2A antibodies were negatively associated with cognitive symptoms.
Conclusions:
- Autoantibodies against ACE2, MAS1, and STAB1 may serve as biomarkers for PACVS.
- An anti-idiotype mechanism is suggested in PACVS immunopathogenesis.
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