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The Role of the Serotonergic System in Time Perception: A Systematic Review
Rauf Akhmirov1, Dina Mitiureva1, Maria Zaichenko1
1Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 117465 Moscow, Russia.
International Journal of Molecular Sciences
|January 8, 2025
Summary
The serotonergic system significantly influences time perception across species. Increased serotonin may speed up internal time, while decreased levels are linked to impulsivity and slower timing.
Area of Science:
- Neuroscience
- Cognitive Science
- Behavioral Science
Background:
- Time perception is crucial for behavior and is modulated by neural mechanisms.
- The specific role of the serotonergic system in time perception requires further clarification.
- Translational research is needed to bridge human and animal findings.
Purpose of the Study:
- To review the role of the serotonergic system in time perception (seconds to minutes).
- To build a translational bridge between human and animal studies on serotonin and timing.
- To synthesize current evidence on serotonin's neuromodulation of temporal cognition.
Main Methods:
- Systematic literature search following PRISMA guidelines.
- Databases searched: PubMed, APA PsycINFO, APA PsycARTICLES.
- Included 60 studies: 10 human and 50 animal.
Main Results:
- Consistent evidence supports serotonin's role in timing behavior across different paradigms.
- Increased serotonin activity generally accelerates internal time perception.
- Decreased serotonin function is linked to impulsivity and slower internal time.
Conclusions:
- Serotonin plays a complex role in modulating time perception.
- The dual klepsydra model offers a framework, but some findings present challenges.
- Further research is needed to understand serotonin's impact on reward-based temporal decisions.
