Multiomics of Aging and Aging-Related Diseases

Area of Science:

• Gerontology and Molecular Biology
• Integrative Omics and Disease Pathogenesis

Background:

• Aging is a fundamental biological process characterized by progressive functional decline in cells and tissues.
• Despite biological diversity, aging is a shared trait across virtually all living organisms.
• Age is a critical factor influencing the risk, severity, and treatment of numerous diseases, including cancer, neurodegeneration, and cardiovascular conditions.

Purpose of the Study:

• To systematically review age-related features in the development of various diseases.
• To investigate disease progression through the lens of multiomics data.
• To connect molecular and cellular changes associated with aging to disease pathogenesis.

Main Methods:

• Systematic literature review focusing on aging and disease.
• Analysis of multiomics data, including genomics, transcriptomics, proteomics, and metabolomics.
• Integration of data to identify common pathways and mechanisms linking aging to disease.

Main Results:

• Identification of key age-related molecular alterations, such as genome instability and somatic mutations.
• Characterization of altered biological pathways and metabolic dysregulation associated with aging.
• Demonstration of how these multiomic changes contribute to the development and progression of age-related diseases.

Conclusions:

• Aging is a significant, multi-faceted contributor to disease development across diverse pathologies.
• Multiomics approaches provide a comprehensive framework for understanding the molecular underpinnings of age-related diseases.
• Further research integrating multiomics can elucidate therapeutic targets for age-related conditions.