Risk Factors Related to Resting Metabolic Rate-Related DNAJC6 Gene Variation in Children with Overweight/Obesity:...

Area of Science:

• Genetics and Molecular Biology
• Pediatric Endocrinology
• Nutritional Science

Background:

• Childhood obesity is a growing public health concern with complex genetic and environmental factors.
• The DNACJ6 gene has been implicated in metabolic regulation, but its specific role in pediatric obesity risk requires further investigation.
• Understanding gene-environment interactions is crucial for developing effective obesity prevention strategies.

Purpose of the Study:

• To investigate the association between DNACJ6 gene variations and alterations in resting metabolic rate (RMR) in children.
• To examine how these genetic variations and RMR changes interact with environmental risk factors in the context of childhood obesity.
• To identify potential genetic markers and dietary factors influencing obesity risk in children aged 8-9.

Main Methods:

• A three-year longitudinal study involving children aged 8-9, with anthropometric, blood biochemistry, and dietary intake data collected.
• Analysis of changes in variables between children classified as non-obese (non-OB) and obese (OB) at the study endpoint.
• Genotyping of nine single nucleotide polymorphisms (SNPs) within the DNACJ6 gene and assessment of their association with obesity-related parameters.

Main Results:

• The obese group exhibited greater increases in RMR, BMI, waist circumference, and systolic blood pressure compared to the non-obese group.
• Specific DNACJ6 SNPs (D-I, D-VII, D-VIII) were associated with increased RMR, BMI, and obesity risk, with mutant alleles significantly increasing BMI risk.
• Higher RMR/body weight ratio correlated with decreased BMI risk, particularly in major alleles, while high retinol intake appeared protective against obesity risk in minor alleles of specific SNPs.

Conclusions:

• The RMR/body weight ratio and dietary fat/retinol intake are significant factors to consider in DNACJ6-gene-based precision medicine for pediatric obesity prevention.
• These findings highlight the importance of personalized approaches, especially for boys, considering genetic predispositions and dietary habits.
• Further research into gene-diet interactions can refine targeted interventions for childhood obesity.