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Exploring the Association Between DTC Obesity-Related Gene Polymorphisms and Obesity Risk Factors in Koreans: Focus
Jiha Kim1,2, Soyoun Lee1, Myoungsook Lee1,2
1Department of Food and Nutrition, Sungshin Women's University, Dobong-ro 76ga-gil 55, Gangbuk-gu, Seoul 01133, Republic of Korea.
Nutrients
|February 27, 2026
Summary
The brain-derived neurotrophic factor (BDNF) rs6265 gene variant is linked to obesity phenotypes in Korean adults. This study provides evidence for personalized nutrition strategies based on genetic risk factors for obesity.
Area of Science:
- Genetics and Genomics
- Nutritional Science
- Obesity Research
Background:
- Obesity is a complex condition with numerous genetic factors.
- Key obesity-related genes like FTO, MC4R, and BDNF are targets for direct-to-consumer genetic testing.
- Limited population-specific data exists for these genes in relation to obesity phenotypes among Koreans.
Purpose of the Study:
- To investigate the association between specific genetic variants (FTO, MC4R, BDNF) and obesity-related phenotypes in a Korean adult population.
- To provide population-specific evidence for the role of these genes in obesity.
- To explore the potential for genotype-based personalized nutrition strategies.
Main Methods:
- A cross-sectional study involving 231 healthy Korean adults (aged 19-64).
- Data collection included anthropometric measurements, clinical data, genotyping, dietary intake assessment, and lifestyle questionnaires.
- Statistical analyses employed ANOVA, ANCOVA, and multivariable-adjusted regression models to assess genotype-phenotype associations.
Main Results:
- The brain-derived neurotrophic factor (BDNF) rs6265 A allele was significantly associated with higher waist-to-hip ratio (WHR), alanine aminotransferase (ALT), HbA1c, and sodium intake compared to the GG genotype.
- BDNF A allele carriers also exhibited higher drinking frequency and elevated ALT levels.
- Significant interactions between genotypes and obesity phenotypes were observed for various metabolic and dietary factors, including resting metabolic rate (RMR), body weight (BW) status, and intake of specific nutrients like Vitamin E and polyunsaturated fatty acids (PUFA).
Conclusions:
- The BDNF rs6265 variant is relevant to obesity phenotypes in Korean adults.
- Findings support the development of Korean-specific, genotype-based nutrition strategies.
- Caution is advised when interpreting personalized nutrition approaches due to the cross-sectional nature of the study.
Keywords:
BDNFDTC genetic testingdietary intakeobesity phenotypesprecision nutritionresting metabolic rate (RMR)More Related Videos
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