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Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

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Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
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Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
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Related Experiment Video

Updated: May 3, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
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Sustained Release of Curcumin from Cur-LPs Loaded Adaptive Injectable Self-Healing Hydrogels.

Caixia Wu1, Xiaoqun Ning2, Qunfeng Liu3

  • 1National Engineering Research Center for Healthcare Devices, Guangdong Provincial Key Laboratory of Medical Electronic Instruments and Materials, Institute of Biological and Medical Engineering, Guangdong Academy of Sciences, Guangzhou 510316, China.

Polymers
|January 8, 2025
PubMed
Summary

A novel injectable hydrogel, synthesized from modified hyaluronic acid, glycol chitosan, and guar gum, effectively repairs irregular tissue defects. It offers rapid gelation, self-healing, and sustained curcumin release for antioxidant and anti-inflammatory tissue repair.

Keywords:
antioxidant and anti-inflammatoryinjectable adhesive self-healing hydrogelrepair of biological tissue defectsustainable release of curcumin

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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Drug Delivery

Background:

  • Biological tissue defects present challenges due to irregular shapes, inflammation, and oxidative stress.
  • Developing injectable, adaptable materials for defect filling and promoting repair is crucial.

Purpose of the Study:

  • To synthesize and characterize a novel injectable hydrogel for tissue defect repair.
  • To evaluate the hydrogel's injectability, tissue adhesion, self-healing, antioxidant, and anti-inflammatory properties.
  • To assess the sustained release of curcumin for enhanced therapeutic effects.

Main Methods:

  • Synthesis of phenylboronic acid modified oxidized hyaluronic acid (OHAPBA).
  • Dynamic crosslinking with catechol group modified glycol chitosan (GCHCA) and guar gum (GG).
  • Loading with curcumin liposomes (Cur-LPs) and characterization of hydrogel properties, including gelation time, injectability, adhesion, self-healing, biocompatibility, and drug release kinetics.

Main Results:

  • The hydrogel exhibited rapid gelation (within 30 s), excellent injectability, tissue adhesion, and self-healing capabilities.
  • Demonstrated good biocompatibility and significant DPPH radical scavenging activity.
  • Achieved sustained release of curcumin for up to 10 days, improving its bioavailability.

Conclusions:

  • The developed hydrogel effectively fills and adheres to irregular tissue defects.
  • Its antioxidant and sustained anti-inflammatory properties, via curcumin release, promote tissue repair.
  • This injectable hydrogel shows significant potential for applications in tissue defect repair.