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Formulating a Horseradish Extract in Phospholipid Vesicles to Target the Skin.

Maria De Luca1,2, Luca Casula3, Carlo Ignazio Giovanni Tuberoso3

  • 1Department of Science, University of Basilicata, Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy.

Pharmaceutics
|January 8, 2025
PubMed
Summary

Horseradish root extract was encapsulated in nanovesicles to improve stability and bioavailability for skin application. These formulations demonstrated biocompatibility and antioxidant properties, offering potential for treating skin disorders.

Keywords:
antioxidantcytocompatibilityextracthorseradish rootnanovesiclesskin delivery

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Area of Science:

  • Phytochemistry
  • Nanotechnology
  • Dermatology

Background:

  • Horseradish (Armoracia rusticana L.) roots are valued in traditional medicine for therapeutic effects.
  • Phytochemicals in horseradish offer health benefits but suffer from low stability and bioavailability.
  • Phospholipid vesicles are a strategy to enhance the efficacy of plant extracts.

Purpose of the Study:

  • To formulate horseradish root extract into nanovesicles for topical application.
  • To evaluate the physicochemical properties, biocompatibility, and antioxidant activity of the nanoformulations.

Main Methods:

  • A hydroalcoholic extract of horseradish roots was prepared and characterized using UPLC-MS and HPLC-PDA.
  • The extract was encapsulated into conventional liposomes and Penetration Enhancer-containing Vesicles (PEVs).
  • Nanovesicle characterization included size, charge, lamellarity, and entrapment efficiency.

Main Results:

  • Nanovesicles were <100 nm, negatively charged, uni/bilamellar, with >85% entrapment efficiency for flavonoids.
  • Both free and nanoformulated extracts exhibited excellent biocompatibility (no hemolysis, no cytotoxicity).
  • Nanoformulations demonstrated significant in vitro antioxidant activity.

Conclusions:

  • Horseradish extract nanoformulations show promise for topical delivery.
  • These nanovesicles can potentially counteract oxidative stress in skin disorders.
  • The study highlights the utility of phospholipid vesicles for enhancing phytochemical efficacy.