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Polarity Sensor Based on Multivariate Lanthanide Metal-Organic Framework for Constructing Biosensing Platform.

Long Yu1,2, Qi Xu1,3, Ling Huang1,3

  • 1Department of Pharmacy, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.

Analytical Chemistry
|January 8, 2025
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Summary
This summary is machine-generated.

Developing novel polarity sensors is crucial for multiscenario detection. This study introduces modular lanthanide metal-organic framework (Ln-MOF) nanoclusters for sensitive and customizable polarity sensing, enabling advanced biosensing applications.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Chemical Sensing

Background:

  • Developing precise polarity sensors for diverse applications remains a significant challenge.
  • Existing biosensors often face limitations in synthesis and customization.

Purpose of the Study:

  • To design and develop a novel, modular, and customizable polarity sensor.
  • To explore the potential of multivariate lanthanide metal-organic framework (Ln-MOF) nanoclusters for sensitive detection.

Main Methods:

  • Modular programming design of ligands for Ln-MOF nanoclusters.
  • Synthesis of specific Ln-MOF compositions (Eu0.1Tb0.9-IPA and Eu0.3Tb0.7-OPA).
  • Experimental validation and density functional theory (DFT) calculations to understand sensing mechanisms.

Main Results:

  • Demonstrated successful customization of Ln-MOFs for different polarity systems.
  • Achieved high-sensitivity detection of trace water in DMSO using Eu0.1Tb0.9-IPA.
  • Eu0.3Tb0.7-OPA enabled rapid (8 min) and sensitive detection of hyaluronidase activity (LOD 0.016 U/L).
  • Ln-MOFs utilize adjustable polar intermolecular interactions for optimal compatibility and sensitivity.

Conclusions:

  • Multivariate Ln-MOF nanoclusters offer a modular, flexible, and cost-effective approach to polarity sensing.
  • These sensors overcome traditional limitations, showing significant potential in biosensing and medical diagnostics.
  • The findings advance the understanding of polarity parameters and enable new polarity-based biosensing platforms.