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Related Experiment Video

Updated: Jul 10, 2026

Fabrication of the Composite Regenerative Peripheral Nerve Interface C-RPNI in the Adult Rat

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Published on: February 25, 2020

Nerve Capping Using Renerve® Synthetic Collagen Conduits for Hand Amputation Neuroma Pain.

Shinsuke Takeda^1,2, Shigeru Kurimoto³, Ryutaro Shibata¹

¹Department of Orthopaedic Surgery, Nagoya City University Graduate School of Medical Science, Nagoya, Japan.

The Journal of Hand Surgery Asian-Pacific Volume

|January 8, 2025

Summary

The Renerve® nerve conduit effectively reduced pain in patients with amputation neuromas. This study highlights its clinical usefulness for nerve capping, offering valuable real-world data for practitioners.

Keywords:

Absorbable implants Amputation neuroma Nerve capping Peripheral nerve injuries Renerve® conduits

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Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management

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Published on: March 15, 2024

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain

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Published on: March 8, 2024

Area of Science:

Peripheral nerve surgery
Regenerative medicine
Pain management

Background:

Amputation neuromas, a frequent outcome of peripheral nerve injury, can lead to debilitating pain and functional impairment.
Surgical intervention, such as nerve capping, is often considered for managing symptomatic neuromas.
The bioabsorbable nerve conduit Renerve® presents a potential solution for nerve capping.

Purpose of the Study:

To evaluate the clinical effectiveness of the Renerve® nerve conduit when used for nerve capping in patients with amputation neuromas.
To assess pain reduction and complication rates following the Renerve® nerve capping procedure.

Main Methods:

A retrospective study was conducted on seven patients with amputation neuromas of the finger or palm.
Patients underwent surgical treatment using the Renerve® conduit for nerve capping between October 2018 and September 2022.
Pre- and postoperative visual analogue scale (VAS) pain scores and Tinel sign were analyzed, with a minimum follow-up of 6 months.

Main Results:

A significant reduction in median VAS pain scores was observed, decreasing from 53.1 mm preoperatively to 5.7 mm at 6-month follow-up.
The median follow-up duration was 15 months, with no postoperative complications reported.
Tinel sign persisted in four out of seven patients post-surgery.

Conclusions:

The Renerve® conduit demonstrates clinical utility as a nerve-capping technique for treating amputation neuromas.
The findings provide valuable real-world data on the use of Renerve® conduits for nerve capping, addressing a gap in current literature.
This technique offers a promising option for managing neuroma pain and improving patient outcomes.