Nodular cutaneous amyloidosis involving the vulva. Case report and literature review

A case of localized nodular cutaneous amyloidosis involving the vulva occurred in a 53-year-old woman. This rare type of cutaneous amyloidosis has been reported in the female genitalia in two prior cases. The unusual aspects of our case were (1) recurrence after six years, (2) an ulcerative appearance clinically simulating a malignant neoplasm, and (3) the presence of numerous Russell bodies. Our histopathologic findings in hematoxylin-eosin-and peroxidase-antiperoxidase-stained sections support the concept of immunoglobulin light chain derivation.