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11C-Methionine PET/CT in Cryptococcus Meningoencephalitis

Yoichi Otomi1, Natsumi Teshima2, Takayoshi Shinya3

  • 1From the Department of Radiology, Tokushima University Hospital, Tokushima, Japan.

Clinical Nuclear Medicine
|January 8, 2025
PubMed

Insights

A 70-year-old man presented with an epileptic seizure. Diagnosis of Cryptococcus meningoencephalitis was confirmed by cerebrospinal fluid analysis, revealing Cryptococcus neoformans.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Neuroimaging

Background:

  • Epileptic seizures can be a presenting symptom of various neurological conditions, including infections.
  • Neuroimaging plays a crucial role in differentiating infectious etiologies from neoplastic processes.

Observation:

  • A 70-year-old male presented with an epileptic seizure.
  • MRI revealed left occipital cortex abnormalities with gadolinium enhancement.
  • 11C-Methionine PET/CT showed increased uptake in the left occipital lobe cortex.

Findings:

  • Cerebrospinal fluid examination identified Cryptococcus neoformans.
  • The findings led to a diagnosis of Cryptococcus meningoencephalitis.

Implications:

  • This case highlights the importance of considering infectious causes, such as Cryptococcus meningoencephalitis, in patients presenting with seizures and focal brain lesions.
  • Integrated neuroimaging (MRI and PET/CT) and cerebrospinal fluid analysis are essential for accurate diagnosis and management.

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