Intensified and Accelerated Rescue Infliximab Therapy for Acute Severe Ulcerative Colitis in Pregnancy: A Case...

Area of Science:

• Gastroenterology and Hepatology
• Obstetrics and Gynecology
• Immunology

Background:

• Acute severe ulcerative colitis (ASUC) during pregnancy presents significant maternal and fetal risks.
• Anti-TNF alpha therapy is generally considered safe in pregnancy, but specific data for ASUC management is limited.

Purpose of the Study:

• To report a successful management strategy for ASUC in early pregnancy.
• To highlight the efficacy of intensified infliximab therapy in this specific clinical scenario.

Main Methods:

• A case report of a 10-week gestation patient with ASUC.
• Administration of intensified and accelerated infliximab therapy (35 mg/kg total dose) during a single admission.
• Multidisciplinary management approach.

Main Results:

• Successful clinical management of ASUC in a pregnant patient.
• Avoidance of colectomy, a high-risk surgical procedure during pregnancy.
• Demonstrated safety and efficacy of the intensified infliximab regimen.

Conclusions:

• Intensified and accelerated infliximab therapy can be a safe and effective treatment for ASUC in pregnancy.
• This therapeutic strategy, as part of a multidisciplinary team, offers an alternative to colectomy.
• Further research is warranted to establish optimal protocols for anti-TNF therapy in pregnant ASUC patients.