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Related Experiment Video

Updated: May 3, 2026

Ischemic Tissue Injury in the Dorsal Skinfold Chamber of the Mouse: A Skin Flap Model to Investigate Acute Persistent Ischemia
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Acute mesenteric ischemia with abdominal skin mottling.

Masahiro Yabe1, Yuji Nomoto2, Hitomi Watanabe3

  • 1Department of General Internal Medicine Niigata City General Hospital Niigata Niigata Japan.

Journal of General and Family Medicine
|January 8, 2025
PubMed
Summary

Sudden skin mottling in a Stage IV lung cancer patient indicated acute mesenteric ischemia, a critical condition of decreased intestinal blood flow. This rare finding highlights skin mottling as a potential early sign of circulatory failure.

Keywords:
abdominal skin mottlingacute mesenteric ischemiacirculatory failureskin mottling

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Area of Science:

  • Geriatric Medicine
  • Oncology
  • Gastroenterology

Background:

  • Stage IV lung cancer patients are often frail and susceptible to sudden medical complications.
  • Acute mesenteric ischemia is a vascular emergency characterized by compromised blood flow to the intestines.
  • Skin mottling can be a sign of poor circulation.

Purpose of the Study:

  • To report a rare case of acute mesenteric ischemia presenting with skin mottling in an elderly cancer patient.
  • To highlight the diagnostic significance of skin mottling in cases of suspected intestinal ischemia.

Main Methods:

  • Case report of a 90-year-old female with Stage IV lung cancer.
  • Clinical observation of sudden onset abdominal and knee skin mottling.
  • Laboratory tests revealing elevated inflammatory markers.
  • Emergent computed tomography (CT) scan for diagnosis.

Main Results:

  • The patient presented with unusual skin mottling.
  • Diagnostic workup confirmed acute mesenteric ischemia.
  • The patient's condition rapidly deteriorated, leading to death within 7 hours.

Conclusions:

  • Abdominal skin mottling can be an early, critical physical finding suggestive of intestinal ischemia.
  • This sign may indicate profound circulatory failure, especially in vulnerable patient populations.
  • Prompt recognition of skin mottling is crucial for timely diagnosis and management of mesenteric ischemia.