Related Experiment Video
Updated: May 3, 2026

Ischemic Tissue Injury in the Dorsal Skinfold Chamber of the Mouse: A Skin Flap Model to Investigate Acute Persistent Ischemia
Published on: November 17, 2014
Acute mesenteric ischemia with abdominal skin mottling
Masahiro Yabe1, Yuji Nomoto2, Hitomi Watanabe3
1Department of General Internal Medicine Niigata City General Hospital Niigata Niigata Japan.
Sudden skin mottling in a Stage IV lung cancer patient indicated acute mesenteric ischemia, a critical condition of decreased intestinal blood flow. This rare finding highlights skin mottling as a potential early sign of circulatory failure.
Area of Science:
- Geriatric Medicine
- Oncology
- Gastroenterology
Background:
- Stage IV lung cancer patients are often frail and susceptible to sudden medical complications.
- Acute mesenteric ischemia is a vascular emergency characterized by compromised blood flow to the intestines.
- Skin mottling can be a sign of poor circulation.
Purpose of the Study:
- To report a rare case of acute mesenteric ischemia presenting with skin mottling in an elderly cancer patient.
- To highlight the diagnostic significance of skin mottling in cases of suspected intestinal ischemia.
Main Methods:
- Case report of a 90-year-old female with Stage IV lung cancer.
- Clinical observation of sudden onset abdominal and knee skin mottling.
- Laboratory tests revealing elevated inflammatory markers.
- Emergent computed tomography (CT) scan for diagnosis.
Main Results:
- The patient presented with unusual skin mottling.
- Diagnostic workup confirmed acute mesenteric ischemia.
- The patient's condition rapidly deteriorated, leading to death within 7 hours.
Conclusions:
- Abdominal skin mottling can be an early, critical physical finding suggestive of intestinal ischemia.
- This sign may indicate profound circulatory failure, especially in vulnerable patient populations.
- Prompt recognition of skin mottling is crucial for timely diagnosis and management of mesenteric ischemia.
Related Concept Videos
Changes in Skin Color: Clinical Perspectives
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Endocarditis II: Clinical Features of Infective Endocarditis
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Aneurysm II: Clinical Manifestations and Diagnostic Studies

