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Ion-Regulated Signal Amplification Optical Microfiber Interferometric DNA Sensor.

Hanglin Lu1,2,3, Li Yang1,2, Yuanpeng Li1,2

  • 1Faculty of Physics Science and Technology, Guangxi Normal University, Guilin, China.

Journal of Biophotonics
|January 8, 2025
PubMed
Summary
This summary is machine-generated.

This study introduces a novel optical microfiber sensor for detecting deoxyribonucleic acid (DNA). The sensor utilizes an ion-regulation mechanism to achieve highly sensitive and precise DNA sequence detection at low concentrations.

Keywords:
DNA sensorion‐regulatedoptical microfibersignal amplification

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Materials Science

Background:

  • Genetic information sensors are crucial in biomedicine.
  • Accurate detection of deoxyribonucleic acid (DNA) is essential for various applications.
  • Existing methods may lack sensitivity or require complex procedures.

Purpose of the Study:

  • To develop a highly sensitive optical microfiber interferometric sensor for DNA detection.
  • To enhance DNA detection sensitivity using an ion-regulation mechanism.
  • To enable the detection of specific single-stranded DNA (ssDNA) sequences at low concentrations.

Main Methods:

  • Fabrication of an optical microfiber with a diameter less than 10 μm using melting and tapering.
  • Utilizing monovalent cations to promote G-rich ssDNA folding into G-quadruplex structures.
  • Implementing an ion-regulation sensitivity enhancement mechanism for detection.

Main Results:

  • Achieved a linear detection range improvement of 3 orders of magnitude.
  • Obtained a limit of detection (LOD) of 1.07 × 10⁻¹⁵ M with the ion-regulation mechanism.
  • Demonstrated the sensor's capability for detecting specific ssDNA sequences at low concentrations.

Conclusions:

  • The developed optical microfiber interferometric sensor offers high sensitivity and simplicity.
  • The ion-regulation mechanism significantly enhances DNA detection performance.
  • This sensing architecture is a promising tool for diverse biosensing and analytical applications.