Related Experiment Video
Updated: May 10, 2026

07:57
Assessing Whole-Body Lipid-Handling Capacity in Mice
Published on: November 24, 2020
Advancing de novo lipogenesis: Genetic and metabolic insights
Sean M Hartig1, Mark A Herman1
1Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Cell Metabolism
|January 8, 2025
Abstract:
De novo lipogenesis (DNL) is the process whereby cells synthesize fatty acids from acetyl-CoA, contributing to steatosis in fatty liver disease. Two new studies, using genetic mouse models, metabolomics, and pharmacology, identified alternative pathways in DNL and unexpected physiological effects when targeting key enzymes in this pathway.

