Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

6.2K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
6.2K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

33.2K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
33.2K
Spermatogenesis01:41

Spermatogenesis

102.1K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.1K
Epigenetic Regulation01:37

Epigenetic Regulation

3.0K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.0K
Chromosomal Theory of Inheritance01:39

Chromosomal Theory of Inheritance

53.9K
In 1866, Gregor Mendel published the results of his pea plant breeding experiments, providing evidence for predictable patterns in the inheritance of physical characteristics. The significance of his findings was not immediately recognized. In fact, the existence of genes was unknown at the time. Mendel referred to hereditary units as “factors.”
53.9K
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

7.4K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
7.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The KIF6-RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Biallelic Variants of CHTF18 Are Associated With Male Infertility With Cryptozoospermia in Humans.

Andrology·2026
Same author

Bi-allelic mutations of CAMSAP1 result in teratozoospermia with sperm head and flagella defects in humans.

Human reproduction (Oxford, England)·2026
Same author

SPEM2 deficiency disrupts spermiation leading to oligoasthenoteratozoospermia and male infertility†.

Biology of reproduction·2026
Same author

A testis-specific E3 ubiquitin ligase complex governs spermiogenesis and male fertility.

Nature communications·2026
Same author

A common cause of non-obstructive azoospermia: biallelic MEI1 variants and implications for infertility diagnostics.

Journal of assisted reproduction and genetics·2026
Same journal

[Advance in the application of molecular ruler-based RNA 3D dynamic analysis for the interpretation of variants of uncertain significance].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics·2026
Same journal

[Identification of a pregnant woman with tetragametic chimera of 46,XY/46,XX karyotype presenting as mixed agglutination during ABO blood group forward typing].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics·2026
Same journal

[Genetic analysis of a Chinese pedigree affected with Hereditary coagulation factor â…¤ deficiency due to compound heterozygous variants IVS24+3A>T and p.Asp2222Gly].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics·2026
Same journal

[A novel TPM1 variant causing Dilated cardiomyopathy in a child: A case report and literature review].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics·2026
Same journal

[Clinical and genetic analysis of a child with Relapsing encephalopathy with cerebellar ataxia due to variant of ATP1A3 gene].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics·2026
Same journal

[Clinical and genetic analysis of a child with MRXS34 syndrome due to variant of NONO gene].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics·2026
See all related articles

Related Experiment Video

Updated: Jun 3, 2025

High-throughput Screening for Protein-based Inheritance in S. cerevisiae
08:12

High-throughput Screening for Protein-based Inheritance in S. cerevisiae

Published on: August 8, 2017

6.3K

[Paternal inheritance mediated by epigenetic changes in sperms].

Yena Hu1, Weili Wang, Chaofeng Tu

  • 1Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Sciences, Central South University, Changsha, Hunan 410078, China. tanyueqiu@sina.com.

Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics
|January 8, 2025
PubMed
Summary
This summary is machine-generated.

Paternal epigenetic changes in sperm can be passed to offspring, influencing their health. This review explores sperm

More Related Videos

Phosphopeptide Analysis of Rodent Epididymal Spermatozoa
09:30

Phosphopeptide Analysis of Rodent Epididymal Spermatozoa

Published on: December 30, 2014

12.9K
Application of Mouse Parthenogenetic Haploid Embryonic Stem Cells as a Substitute of Sperm
08:08

Application of Mouse Parthenogenetic Haploid Embryonic Stem Cells as a Substitute of Sperm

Published on: November 19, 2020

4.5K

Related Experiment Videos

Last Updated: Jun 3, 2025

High-throughput Screening for Protein-based Inheritance in S. cerevisiae
08:12

High-throughput Screening for Protein-based Inheritance in S. cerevisiae

Published on: August 8, 2017

6.3K
Phosphopeptide Analysis of Rodent Epididymal Spermatozoa
09:30

Phosphopeptide Analysis of Rodent Epididymal Spermatozoa

Published on: December 30, 2014

12.9K
Application of Mouse Parthenogenetic Haploid Embryonic Stem Cells as a Substitute of Sperm
08:08

Application of Mouse Parthenogenetic Haploid Embryonic Stem Cells as a Substitute of Sperm

Published on: November 19, 2020

4.5K

Area of Science:

  • Epigenetics and reproductive biology.
  • Genetics and environmental influences on health.
  • Intergenerational and transgenerational inheritance.

Background:

  • Epigenetics links genome and environment, mediating responses to factors like diet, stress, and age.
  • Epigenetic modifications (DNA methylation, non-coding RNA, histone modifications) act as cellular memory.
  • Sperm possess unique epigenetic profiles and are highly sensitive to environmental influences.

Purpose of the Study:

  • To review epigenetic mechanisms of paternal inter-/trans-generational inheritance.
  • To summarize recent studies on sperm-mediated epigenetic inheritance in humans and mice.
  • To enhance understanding of paternal epigenetic changes' impact on offspring health.

Main Methods:

  • Literature review of epigenetic mechanisms.
  • Analysis of studies on paternal inheritance via sperm epigenetics.
  • Synthesis of findings from human and mouse models.

Main Results:

  • Sperm epigenetic changes are implicated in paternal inter-/trans-generational inheritance.
  • Environmental and physiological factors can alter sperm epigenetics.
  • These alterations correlate with offspring health outcomes.

Conclusions:

  • Paternal epigenetic inheritance via sperm is a significant factor in offspring health.
  • Understanding these mechanisms is crucial for genetic counseling and clinical interventions.
  • Further research can elucidate the precise links between paternal epigenetics and health across generations.