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Visual Agnosia

Visual Agnosia

Visual agnosia is a condition characterized by the inability to recognize visually presented objects despite having normal vision. For instance, a person with visual agnosia can describe the shape and color of an object but cannot identify or name it. This impairment does not affect their visual field, acuity, color vision, brightness discrimination, language, or memory. An example of this condition in a social setting is someone at a dinner party asking for "that silver thing with a round...

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Related Experiment Video

Updated: May 5, 2026

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

Published on: September 25, 2019

Voxel-Based Lesion-Symptom Mapping Localizes Residual Visual Function in Hemianopia.

Hanna E Willis¹, Junaid Hameed¹, Lucy Starling¹

¹Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford OX3 9DU, United Kingdom.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

|January 8, 2025

Summary

This summary is machine-generated.

Residual vision in hemianopia is not solely dependent on primary visual cortex (V1) damage. Specific areas like hMT+/V5 and the optic radiation are critical for visual field recovery after brain injury.

Keywords:

blindsight hemianopia motion primary visual cortex (V1)residual vision voxel-based lesion–symptom mapping (VLSM)

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Development of a Gaze-Contingent Display Framework Designed for Perceptual and Oculomotor Research with Simulated Central Vision Loss

Published on: April 11, 2025

Area of Science:

Neuroscience
Visual Neuroscience
Clinical Neurology

Background:

Damage to the primary visual cortex (V1) causes contralateral visual field deficits.
Patients with V1 damage often exhibit residual vision, but the underlying neural mechanisms remain unclear.
Previous studies were limited by small sample sizes.

Purpose of the Study:

To investigate the neural correlates of residual vision in patients with hemianopia.
To identify specific brain regions crucial for retaining vision in damaged visual fields.

Main Methods:

Structural MRI scans from 39 hemianopic patients were analyzed.
Voxel-based lesion-symptom mapping (VLSM) was used to correlate lesion location with visual task performance.
Damage extent in visual cortex areas (V1, V4, hMT+/V5) was quantified.

Main Results:

V1 damage extent did not correlate with residual vision.
Damage to V4 and hMT+/V5 correlated with contrast detection.
Damage to hMT+/V5 significantly impaired performance on all visual tasks, especially motion detection.
VLSM identified lateral optic radiation damage as highly associated with poor residual vision.

Conclusions:

hMT+/V5 and the optic radiation are critical for residual vision in hemianopia.
While hMT+/V5 appears necessary, it is not sufficient for residual vision.
VLSM provides precise localization of neural substrates for residual vision.