Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

173
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
173
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

281
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
281
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

114
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
114
Factors Influencing Drug Absorption: Drug Dissolution01:27

Factors Influencing Drug Absorption: Drug Dissolution

408
The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
408
Factors Influencing Drug Absorption: Physicochemical Parameters01:22

Factors Influencing Drug Absorption: Physicochemical Parameters

214
The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
214
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

719
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
719

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<b>Quantification of 14 Major and Minor Cannabinoids with Absorbance</b>-<b>Transmittance Excitation</b>-<b>Emission Matrix Spectroscopy and Machine Learning</b>.

Cannabis and cannabinoid research·2026
Same author

High-loading hyaluronic acid dissolving microneedles for child-friendly dermal and transdermal delivery of doxycycline.

International journal of pharmaceutics·2026
Same author

Development and Validation of an HPLC-UV/PDA Method for the Determination of Cannflavins in Different <i>Cannabis sativa</i> Chemovars.

Methods and protocols·2025
Same author

Piperine solubility enhancement via DES formation: Elucidation of intermolecular interactions and impact of counterpart structure via computational and spectroscopic approaches.

International journal of pharmaceutics·2024
Same author

Effect of Gamma Irradiation on Cannabinoid, Terpene, and Moisture Content of Cannabis Biomass.

Molecules (Basel, Switzerland)·2023
Same author

Validation and Quantitation of Fifteen Cannabinoids in Cannabis and Marketed Products Using High-Performance Liquid Chromatography-Ultraviolet/Photodiode Array Method.

Cannabis and cannabinoid research·2023

Related Experiment Video

Updated: Jun 3, 2025

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
11:27

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

2.0K

New Ionic Liquid Forms of Antituberculosis Drug Combinations for Optimized Stability and Dissolution.

Hanan E Rasmy1, Sara A Abouelmagd2,3, Elsayed A Ibrahim1,4

  • 1Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt.

AAPS Pharmscitech
|January 8, 2025
PubMed
Summary

Active pharmaceutical ingredient-ionic liquids (API-ILs) were developed for isoniazid (INH) and rifampicin (RIF) to improve tuberculosis treatment. API-ILs enhanced drug stability and dissolution, offering a promising approach for fixed drug combinations.

Keywords:
dissolutionionic liquidisoniazidrifampicinstability

More Related Videos

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
09:47

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

9.6K
Synthesis of Ionic Liquid Based Electrolytes, Assembly of Li-ion Batteries, and Measurements of Performance at High Temperature
11:04

Synthesis of Ionic Liquid Based Electrolytes, Assembly of Li-ion Batteries, and Measurements of Performance at High Temperature

Published on: December 20, 2016

12.9K

Related Experiment Videos

Last Updated: Jun 3, 2025

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
11:27

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

2.0K
Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
09:47

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

9.6K
Synthesis of Ionic Liquid Based Electrolytes, Assembly of Li-ion Batteries, and Measurements of Performance at High Temperature
11:04

Synthesis of Ionic Liquid Based Electrolytes, Assembly of Li-ion Batteries, and Measurements of Performance at High Temperature

Published on: December 20, 2016

12.9K

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Ionic Liquids

Background:

  • Tuberculosis treatment relies on isoniazid (INH) and rifampicin (RIF), often in fixed combinations.
  • Suboptimal solubility and physical instability challenge the delivery of INH and RIF.
  • Active pharmaceutical ingredient-ionic liquids (API-ILs) offer a novel approach to enhance drug properties.

Purpose of the Study:

  • To explore the potential of API-ILs for improving the physicochemical and pharmaceutical properties of INH and RIF.
  • To develop stable and compatible fixed drug combinations of INH and RIF.
  • To enhance the dissolution rate and extent of RIF.

Main Methods:

  • Isoniazid (INH) and rifampicin (RIF) were paired with counter ions (ascorbic acid, citric acid, etc.) using solvent evaporation.
  • Formation of API-ILs was confirmed using FTIR, XRPD, and POM.
  • Storage stability and dissolution rates of API-ILs and physical mixtures were evaluated.

Main Results:

  • Successful formation of INH and RIF API-ILs with ascorbic acid and citric acid counter ions.
  • XRPD and POM confirmed the amorphous nature of the API-ILs.
  • API-IL formation enhanced the storage stability of INH+RIF mixtures and significantly increased RIF dissolution rate and extent.

Conclusions:

  • API-IL formation is a viable strategy to improve the solubility, stability, and compatibility of INH and RIF.
  • This approach facilitates the development of stable, fixed-dose combinations for tuberculosis management.
  • RIF-CA API-IL demonstrated superior dissolution enhancement compared to physical mixtures.